Trending...
- AI Visibility: The Key to Beating Google's AI Overviews and Regaining Traffic
- New Mobile Car Detailing Platform Connects Drivers with On-Demand Local Pros
- Cal State LA secures funding for two artificial intelligence projects from CSU
SAN DIEGO, Dec. 7, 2024 ~ At the 66th Annual Meeting of the American Society of Hematology (ASH) in San Diego, Calif., groundbreaking results from a major clinical trial were revealed today. The trial, supported in part by the St. Baldrick's Foundation, has the potential to redefine the standard of care for children with acute lymphoblastic leukemia (ALL).
The Children's Oncology Group (COG) announced transformative findings that have been hailed as one of the most significant advancements in pediatric oncology in decades. This milestone is a result of 25 years of donations to St. Baldrick's head-shaving events, fundraisers, and the generosity of dedicated donors.
As COG's largest philanthropic donor, St. Baldrick's plays a crucial role in funding groundbreaking discoveries and clinical trials that bring these innovations to patients. Through COG's cooperative research network, thousands of children gain access to lifesaving clinical trials each year. Currently, more than 100 trials are actively recruiting participants. The annual grant from St. Baldrick's helps cover the cost of these trials by providing per-patient reimbursements to member institutions, ensuring that more children have access to cutting-edge treatments.
More on The Californer
The latest trial conducted by COG demonstrates that adding blinatumomab, a targeted immunotherapy drug, to traditional chemotherapy significantly improves disease-free survival (DFS) rates for children with standard-risk (SR) ALL. The results are so impactful that all ongoing SR ALL trials have been suspended by COG to incorporate this game-changing treatment into its protocols.
The trial enrolled over 4,200 children and achieved unprecedented results:
- A 96% three-year DFS rate for children receiving blinatumomab compared to 87.9% with chemotherapy alone.
- Blinatumomab was shown to be well-tolerated with minimal severe side effects, paving the way for reducing the use of older and more toxic chemotherapy drugs.
Dr. Doug Hawkins, COG Group Chair, stated, "Blinatumomab represents a paradigm shift in how we treat ALL. For the first time, we can envision replacing toxic treatments with a safer, targeted therapy without compromising, and even improving, survival rates. We are grateful for the support of so many donors who helped make this discovery possible, including the St. Baldrick's Foundation."
Blinatumomab is a type of immunotherapy and monoclonal antibody that targets CD19, a protein found on leukemia cells. By engaging the body's immune system, the drug enables it to recognize and destroy cancerous cells more effectively. Unlike traditional chemotherapy, blinatumomab shows no evidence of causing long-term side effects, which is especially critical for young patients.
More on The Californer
The success of this trial highlights the crucial role of philanthropic support in advancing pediatric cancer research. To date, St. Baldrick's has granted over $101 million to COG, empowering them to explore cutting-edge treatments like blinatumomab and changing the outlook for children diagnosed with ALL.
Kathleen Ruddy, CEO of the St. Baldrick's Foundation said, "This transformative breakthrough represents a monumental step forward in our fight to conquer kids' cancer. Thanks to the unwavering support of our donors, volunteers, partners and advocates, we're not only improving survival rates but also paving the way for safer, less toxic treatments. Together we are making cures a reality."
With these groundbreaking results from COG's trial using blinatumomab for ALL treatment in children with SR ALL patients can look forward to a new era in treatment options that are both safer and more effective. The medical community is optimistic about extending this treatment approach to other childhood cancers as researchers continue to build on this success.
For more information about the St. Baldrick's Foundation and how you can support lifesaving pediatric cancer research, visit StBaldricks.org.
The Children's Oncology Group (COG) announced transformative findings that have been hailed as one of the most significant advancements in pediatric oncology in decades. This milestone is a result of 25 years of donations to St. Baldrick's head-shaving events, fundraisers, and the generosity of dedicated donors.
As COG's largest philanthropic donor, St. Baldrick's plays a crucial role in funding groundbreaking discoveries and clinical trials that bring these innovations to patients. Through COG's cooperative research network, thousands of children gain access to lifesaving clinical trials each year. Currently, more than 100 trials are actively recruiting participants. The annual grant from St. Baldrick's helps cover the cost of these trials by providing per-patient reimbursements to member institutions, ensuring that more children have access to cutting-edge treatments.
More on The Californer
- Mike Diamond Offers Free Sewer Camera Inspections to Help Homeowners Catch Problems Early
- Mike Diamond Offers $99 Priority & Premium Air Conditioning Protection in Anaheim, CA
- Garmin Approach R50: Redefining Home Golf Simulation
- California: Governor Newsom statement on the court temporarily blocking the Trump Administration's unlawful immigration tactics in the Los Angeles area
- Governor Newsom urges Californians to take precautions as state endures triple digit heat, smoky conditions
The latest trial conducted by COG demonstrates that adding blinatumomab, a targeted immunotherapy drug, to traditional chemotherapy significantly improves disease-free survival (DFS) rates for children with standard-risk (SR) ALL. The results are so impactful that all ongoing SR ALL trials have been suspended by COG to incorporate this game-changing treatment into its protocols.
The trial enrolled over 4,200 children and achieved unprecedented results:
- A 96% three-year DFS rate for children receiving blinatumomab compared to 87.9% with chemotherapy alone.
- Blinatumomab was shown to be well-tolerated with minimal severe side effects, paving the way for reducing the use of older and more toxic chemotherapy drugs.
Dr. Doug Hawkins, COG Group Chair, stated, "Blinatumomab represents a paradigm shift in how we treat ALL. For the first time, we can envision replacing toxic treatments with a safer, targeted therapy without compromising, and even improving, survival rates. We are grateful for the support of so many donors who helped make this discovery possible, including the St. Baldrick's Foundation."
Blinatumomab is a type of immunotherapy and monoclonal antibody that targets CD19, a protein found on leukemia cells. By engaging the body's immune system, the drug enables it to recognize and destroy cancerous cells more effectively. Unlike traditional chemotherapy, blinatumomab shows no evidence of causing long-term side effects, which is especially critical for young patients.
More on The Californer
- Yvette Kendall Secures $6 Million Deal with The Sessions Studios for Horror Thriller, "NORTH"
- Buy The Crave Launches Premium Creatine and Natural Wellness Supplements for Modern Lifestyles
- Long Beach Parks, Recreation and Marine's Homeland Cultural Center Presents DanceFest at Cesar Chavez Park Amphitheater on August 16
- Sisu, a Portrait of Grit, Connection and Triumph, Premieres on Documentary Showcase
- New Liz Taylor Book Coming Soon: Chasing Elizabeth Taylor
The success of this trial highlights the crucial role of philanthropic support in advancing pediatric cancer research. To date, St. Baldrick's has granted over $101 million to COG, empowering them to explore cutting-edge treatments like blinatumomab and changing the outlook for children diagnosed with ALL.
Kathleen Ruddy, CEO of the St. Baldrick's Foundation said, "This transformative breakthrough represents a monumental step forward in our fight to conquer kids' cancer. Thanks to the unwavering support of our donors, volunteers, partners and advocates, we're not only improving survival rates but also paving the way for safer, less toxic treatments. Together we are making cures a reality."
With these groundbreaking results from COG's trial using blinatumomab for ALL treatment in children with SR ALL patients can look forward to a new era in treatment options that are both safer and more effective. The medical community is optimistic about extending this treatment approach to other childhood cancers as researchers continue to build on this success.
For more information about the St. Baldrick's Foundation and how you can support lifesaving pediatric cancer research, visit StBaldricks.org.
Filed Under: Business
0 Comments
Latest on The Californer
- City of Long Beach Opens Applications for Cannabis Equity Program
- Ridgeback Lighting Launches Battery-Free EBL LED Emergency and Egress Light
- Long Beach: Health Department Announces Certification of 32 Community Violence Intervention Workers
- Easton & Easton, LLP Files Suit Against The Dwelling Place Anaheim & Vineyard USA Over Abuse Allegations
- AI Visibility: The Key to Beating Google's AI Overviews and Regaining Traffic
- First Partner highlights apprenticeship program helping underrepresented youth break into careers in California's iconic entertainment industry
- Stuck Doing Math or Figuring Out Life's Numbers? Calculator.now Makes It Stupidly Simple
- Cal State LA secures funding for two artificial intelligence projects from CSU
- Colbert Packaging Announces WBENC Recognition
- New Mobile Car Detailing Platform Connects Drivers with On-Demand Local Pros
- Over the past three months, California seized $476 million worth of unlicensed cannabis products
- California scores more clean energy records: 9 in 10 days this year partially powered by 100% clean energy
- "Mobile Suit Gundam" Takes Over San Diego Comic-Con 2025
- DivX Empowers Media Enthusiasts with Free Expert Guides for Advanced MP4 Management
- Assent Expands Executive Team to Accelerate Global Growth & Innovation
- The World's Largest Green Economic Revolution Emerges as Nature, Tech, and Finance Converge
- Hamilton Zanze Sponsors the Acquisition of Two Garden-Style Communities in Reno Area
- Meet a Scientologist Captures Greece's Timeless Beauty with Videographer Lambros Malamas
- Vinnetwork Unveils Decentralized AI Platform with Vinnetwork(VIN) Token to Challenge Tech Giants' Data Monopoly
- Moovs Launches Advanced Contact Center Solution for Large-Scale Transportation Operations