CD38 (Cyclase) Inhibitor Screening Kit (Fluorometric)
The Californer/10158768

MILPITAS, Calif. - Californer -- Cluster of differentiation 38 (CD38), also known as cyclic ADP ribose hydrolase or ADP-ribosyl cyclase is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of Nicotinamide Adenine Dinucleotide (NAD) to Nicotinamide and ADP-ribose (ADPR). Additionally, CD38 generates second messengers, cyclic ADP-ribose using NAD as the substrate. Due to its role in NAD+ metabolism, the study of CD38 and its functions has been of great importance.

It is found on the surface of many immune cells, including plasma B cells, natural killer cells, CD4+, CD8+, etc. Elevated levels of CD38 are associated with aging, obesity, diabetes, heart disease, asthma, inflammation and tumorigenesis etc. BioVision's CD38 (Cyclase) Inhibitor Screening Kit is a plate-based fluorometric assay designed to screen, study and characterize potential inhibitors of CD38 cyclase activity. The assay utilizes a selective CD38 substrate to generate a fluorescent signal measured at Ex/Em = 300/410 nm.

More on The Californer

• Codie Sanchez Reviews - This Contrarian Has a Lot to Say
• Breaking News: She's Looking Good (Robot Mix) by Rodger Collins
• ALERT: Alfi, Inc. Investors with Substantial Losses Have Opportunity to Lead Class Action Lawsuit - ALF; ALFIW
• A Unique Gift for the Person that Has Everything – A Soul Song Composed Just for Them
• The Law Offices of Frank R. Cruz Announces the Filing of a Securities Class Action on Behalf of Alfi, Inc. (ALF, ALFIW) Investors

In the presence of potential CD38 cyclase inhibitors, the fluorescent signal is reduced. The assay is quick, easy, and sensitive for high-throughput screening of CD38 inhibitors. Additionally, the kit includes a CD38 Inhibitor as a control inhibitor.

Figure: Inhibition of CD38 cyclase activity by Quercetin. IC50 was calculated to be 5.2 ± 0.8 μM. Assay was performed following the kit protocol.

Storage Conditions -20ºC
USAGE For Research Use Only! Not For Use in Humans.
For more information on this Assay Kit Cat# K2102 https://bit.ly/30wP71F