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SAN LUIS OBISPO, Calif. - Californer -- Ivermectin, a medication recognized with a Nobel Prize for its impact on global health, continues to be a subject of both established medical use and ongoing scientific inquiry. While widely known for its efficacy against parasitic infections, recent scientific interest has also explored its potential in other therapeutic areas, including cancer. Ivermectin is an antiparasitic drug that has been a cornerstone in treating various parasitic diseases in humans for decades. It is FDA-approved for conditions such as intestinal strongyloidiasis and onchocerciasis, playing a critical role in mass drug administration campaigns that have significantly reduced the burden of these debilitating diseases worldwide. Its mechanism of action involves paralyzing and killing parasites. Topical formulations of ivermectin are also approved for conditions like head lice and rosacea. Ivermectin has garnered attention in the scientific community for its potential in other areas, notably in cancer research. Pre-clinical studies (laboratory and animal models) have indicated that ivermectin may exhibit anti-cancer properties by influencing various cellular pathways involved in tumor growth, metastasis, and drug resistance. These early findings suggest potential mechanisms by which ivermectin could inhibit cancer cell proliferation and enhance the effectiveness of conventional cancer therapies. It is crucial to emphasize that while these preliminary findings are a subject of scientific investigation, ivermectin is NOT an FDA-approved treatment for any form of cancer. Research into ivermectin's role in oncology is currently in its early phases, primarily in laboratory settings and limited, early-phase human clinical trials (e.g., Phase I/II studies for specific cancers, often in combination with other immunotherapies). Medical experts strongly caution against the use of ivermectin for cancer treatment outside of controlled clinical trial settings. Self-medication with ivermectin for cancer is not recommended, as its safety and effectiveness for this purpose in humans have not been established. Furthermore, using unapproved medications can lead to serious side effects, drug interactions, and may delay or interfere with proven cancer treatments. Patients with any medical condition, including parasitic infections or cancer, should always consult with qualified healthcare professionals for diagnosis, treatment, and guidance. Relying on unverified information or obtaining medications from unregulated online sources can pose significant health risks. The ongoing research into ivermectin's potential broader applications highlights the continuous quest for new therapeutic strategies. However, until robust, large-scale human clinical trials demonstrate clear safety and efficacy, its use should remain strictly within its approved indications or under the direct supervision of medical professionals.

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