Trending...
- Submissions of Short Films & Videos are Needed for the 10th Annual Indigenous Film Retreats - 171
- Boomin Reunion Band Itsy Bitsy Teenie Weenie Yellow Polka Dot Bikini Has 10 Million You Tube Streams - 154
- AdvisorVault's 17a-4 Managed 365 Service: Finally, Guaranteed FINRA Compliance On The Microsoft Cloud
LOS ANGELES - Californer -- Autopsy has a central role in shedding light on diseases, helping to uncover the cause of death. Tissue samples from various organs are sampled, stained, and examined under a light microscope to evaluate their histological characteristics. However, chemical staining of autopsy samples often suffers from fixation-related artifacts due to unavoidable delays in tissue preservation. Tissue fixation delay leads to autolysis, a cellular self-digestion process, resulting in a series of perturbations in the tissue environment. These changes interfere with the normal binding of staining dyes and biomolecules in the tissue, thereby diminishing the quality of chemical staining and impacting the clarity and reliability of autopsy outcomes. Moreover, the current workflow for chemical staining is costly, time-consuming, and labor-intensive. Meeting the quality control demands of staining reagents, laboratory infrastructure, and skilled labor becomes challenging during global health emergencies, such as the COVID-19 pandemic, when histopathology services become limited, exacerbating the delays in post-mortem processing. These factors increase staining artifacts observed in autopsy samples.
More on The Californer
In a recent work published in Nature Communications, a UCLA research team led by Professor Aydogan Ozcan developed an AI-powered computational staining approach for label-free autopsy tissue samples, which digitally transforms autofluorescence microscopic images of autopsy tissue sections into their high-quality hematoxylin and eosin (H&E) stained counterparts using a trained neural network model. This virtual staining method was proven to mitigate autolysis-induced artifacts inherent in traditional chemical staining of autopsy samples. It revealed the nuclear, cytoplasmic, and extracellular features clearly, particularly in tissue samples severely affected by autolysis, such as COVID-19 samples, where notable delays in tissue preservation occurred.
To further demonstrate the effectiveness of this autopsy virtual staining technique and ensure its superior performance, four board-certified pathologists blindly evaluated the staining quality of test images from autopsy samples without knowing which image was virtually stained or chemically stained. They confirmed that there was no significant difference between the virtually stained and chemically stained H&E images for the well-preserved autopsy tissue regions in terms of nuclear detail, cytoplasmic detail, and extracellular detail, underscoring the efficacy of this technique. In addition to mitigating autolysis-induced artifacts observed in traditional chemical staining of autopsy samples, this virtual staining technique is also faster, more repeatable and cost-effective, eliminating toxic reagents and manual labor involved in the traditional staining workflow, and therefore holds substantial potential for widespread applications in histology field.
More on The Californer
Article: https://www.nature.com/articles/s41467-024-46077-2
More on The Californer
- Fernanda Rocha Launches New YouTube Fitness Channel, Empowering Busy Moms to Prioritize Their Health
- AI-based Tissue Staining to Detect Amyloid Deposits Without Chemical Stains or Microscopy
- California: Governor Newsom welcomes the largest CHP graduating class in over two years
- California's earthquake warning system notified millions ahead of today's Southern California quake
- Long Beach Airport Seeks Community Votes to Make USA Today's Top 10 List of Small Airports
In a recent work published in Nature Communications, a UCLA research team led by Professor Aydogan Ozcan developed an AI-powered computational staining approach for label-free autopsy tissue samples, which digitally transforms autofluorescence microscopic images of autopsy tissue sections into their high-quality hematoxylin and eosin (H&E) stained counterparts using a trained neural network model. This virtual staining method was proven to mitigate autolysis-induced artifacts inherent in traditional chemical staining of autopsy samples. It revealed the nuclear, cytoplasmic, and extracellular features clearly, particularly in tissue samples severely affected by autolysis, such as COVID-19 samples, where notable delays in tissue preservation occurred.
To further demonstrate the effectiveness of this autopsy virtual staining technique and ensure its superior performance, four board-certified pathologists blindly evaluated the staining quality of test images from autopsy samples without knowing which image was virtually stained or chemically stained. They confirmed that there was no significant difference between the virtually stained and chemically stained H&E images for the well-preserved autopsy tissue regions in terms of nuclear detail, cytoplasmic detail, and extracellular detail, underscoring the efficacy of this technique. In addition to mitigating autolysis-induced artifacts observed in traditional chemical staining of autopsy samples, this virtual staining technique is also faster, more repeatable and cost-effective, eliminating toxic reagents and manual labor involved in the traditional staining workflow, and therefore holds substantial potential for widespread applications in histology field.
More on The Californer
- Atlas Elite Entertainment Releases New Single "Forever"
- If You're Reading This, You May Have Too Much Time on Your Hands!
- "Monotheism and Devils" is the theologically dedicated sequel of "Prince of Eurasia" of the Islamic cleric and executive producer Prince Oak Oakleyski
- CII presented 2024 Connie Award to Guenther and Taylor given Lifetime Achievement Award
- Long Beach Seeks Volunteers for 40th Annual California Coastal Cleanup Day, September 21
Article: https://www.nature.com/articles/s41467-024-46077-2
Source: ucla ita
Filed Under: Science
0 Comments
Latest on The Californer
- JRK Property Holdings Acquires Apartment Communities in San Francisco and Minneapolis
- Long Beach City Council Adopts Fiscal Year 2025 Budget
- New Book Promises to Revolutionize Mindsets and Transform Professional Success for Latinas
- California: Governor Newsom signs "smash-and-grab" bill to strengthen felony sentences for large-scale theft offenses
- Pylontech US Showcases at RE+ 2024 USA - English APAC - Traditional Chinese USA - English
- Diversified Industrial Acquisition Agreement, Plus Major Contract Award for Large Fleet Trucking Provider: MingZhu Logistics: Stock Symbol: YGMZ
- Parking Management Services of America Reports Year-Over-Year Growth and Raises 2025 Sales Guidance
- Award winning author's science fiction novel THE HUMMINGBIRD WHISPERER is available for pre-order
- Messageware Z-Day Guard v1.5 Expands MDR Security to Azure, Exchange, and Windows Servers
- Carlsbad, California Grandma Ignites a National Movement: How a Child's Simple Act of Acknowledgment is Leading the Way to Heal America's Mental Health Crisis
- Huma Raises $38M to Hyper-scale its Payment Financing (PayFi) Network USA - English USA - Turkish
- Hiconics Unveils Innovative Home Energy Solutions at RE+ 2024, Leading Green Energy Trends in North America USA - English USA - English
- SYM Investors Have Opportunity to Lead Symbotic Inc. Securities Fraud Lawsuit
- California: Governor Newsom proclaims state of emergency in response to Bridge and Airport fires, visits Line Fire Incident Command Post
- Horror Short BABUSHKA From Thorny Devil Productions and Five-Tool Player Embark On Festival Journey
- City of Long Beach to Launch Residential Organics Collection Program
- The Ripple Effect Arts, has launched its latest product, Organic Wild Yam Cream, capitalizing on the company's recent viral success on TikTok
- Prince of Eurasia: Monotheism and Devils — the ultrarare Eurasian theological documentary of executive producer Prince Oak Oakleyski
- Sunmed | Your CBD Store Responds to Governor Newsom's Industry-Killing Hemp Regulation
- Secret Room Events Invite Media and Press to Cover the 2024 Red Carpet Lounge in Honor of Nomin