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SAN LUIS OBISPO, Calif. - Californer -- Hydroxychloroquine, commonly known by the brand name Plaquenil, is a medication with both antimalarial and immunomodulatory properties. While initially used to treat malaria, its broader benefits in autoimmune diseases like lupus and rheumatoid arthritis have made it a cornerstone treatment for these conditions.

• Malaria: To treat and prevent malaria caused by certain species of Plasmodium parasites. However, due to rising drug resistance, its effectiveness against some strains of Plasmodium falciparum is limited.
• Rheumatoid Arthritis (RA): To reduce pain, swelling, and inflammation associated with RA. It may also help prevent joint damage and disability.
• Systemic Lupus Erythematosus (SLE): Considered the first-line treatment for SLE, it helps manage symptoms, reduce disease activity, and prevent flare-ups. It is also used in neonatal lupus and cutaneous lupus.
• Chronic Discoid Lupus Erythematosus (CDLE): To treat this less common type of lupus, affecting the skin.

Benefits in autoimmune conditions:

• Reduces inflammation: HCQ calms the overactive immune system in autoimmune diseases, decreasing inflammation and preventing flares.
• Fewer disease flares: It can significantly decrease the frequency and severity of flare-ups in lupus patients.
• Protects against organ damage: HCQ can help prevent long-term damage to organs like the kidneys, heart, and lungs in lupus.
• Improves symptoms: Patients with RA and lupus often experience improvement in skin and joint symptoms, fatigue, and mouth sores.
• Better long-term outcomes: Studies have shown increased long-term survival rates and reduced complications in lupus patients who consistently take HCQ.
• Safety profile: HCQ is generally well-tolerated, with fewer severe side effects compared to other immunosuppressant drugs used in autoimmune conditions.

Off-label uses and areas of research:

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While not officially approved, HCQ is sometimes prescribed off-label for other conditions like dermatomyositis, porphyria cutanea tarda, Q fever, sarcoidosis, and Sjögren syndrome.

Research continues to explore additional potential benefits of HCQ, including:

• Delaying lupus onset: Some studies suggest it might delay progression to SLE in individuals with high risk factors.
• Antiviral activity: Initial interest in its antiviral potential against SARS-CoV-2 (COVID-19) led to numerous studies, but the evidence did not support its efficacy in treating or preventing the virus, according to Science | AAAS.
• Potential in cancer therapy: In vitro and in vivo studies are investigating its potential use as an adjunct to cancer therapies, though this area requires further research, particularly concerning the high doses that might be required.
• Metabolic benefits: HCQ has shown associations with improved lipid profiles and lower blood glucose levels, suggesting potential cardiovascular benefits.

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